MARCO RAGUSA HOME PAGE

Curriculum

June 2002: Graduated summa cum laude in Biological Sciences at University of Catania in 2002, with the dissertation "In Silico and In Vitro Biology in the Post-Genomic Era".

May – June 2002: Research assistant on the project: “Apoptosis Induction by Proton Beams: Molecular and Cellular Effects” for Biomedical Science Department, Catania University.

Nov 2002: Teacher in: “Master in biotecnologia per la difesa sostenibile delle colture e delle produzioni agro-alimentari”, Scuola Superiore Catania.

Apr – June 2003: Research assistant on the project: “Analysis of expression levels for ATM protein in PC3 cells after irradiation with proton beams”, in collaboration with Physics and Astronomy Department, Catania University.

Feb – June 2004: Research assistant on the project “Isolation and Identification of PHA - synthetase genes, in collaboration with Science and Technology Park of Sicily.

June 2004-2006: Tutor for International School of Advanced BioMedicine and BioInformatics.

Mar - May 2004-2006: Teacher in bioinformatics for second level degree courses.

March 2007: PhD in "Endocrinology Sciences: Molecular Basis of Hormonal Action" at the Faculty of Medicine of University of Catania in 2007, with the dissertation "The Apoptotic Machinery as a Biologic Complex System: analysis of its Omics and identification of Candidate Genes for breast Adenocarcinoma, Neuroblastoma and thyroid Adenocarcinoma", tutor Prof. Michele Purrello.

May 2007 – May 2009: Research fellowship in “Molecular Bases of Neuroblastoma”.

Oct 2007-2009: Member of Scientific Committee for International School of Advanced BioMedicine and BioInformatics. Acitrezza (IT).

2008 to present: Teacher in Applied Biology for the Course of Nursing Sciences at the Faculty of Medicine of University of Catania

November – December 2008: Research Visit to School of Chemistry, University of Edinburgh to collaborate with Dr R Sanchez to project “MicroRNA silencing by microspheres”.

2009 to present: Teacher in Biology and Genetics for the Course of Medicine at the Faculty of Medicine of University of Catania

2010: Research grant for the project “BioMedicina Molecolare dei Sistemi Complessi: Analisi Molecolare delle Omiche nel Carcinoma del Colon e del Retto ed Applicazioni Cliniche”, coordinated dal Prof. M Purrello.

From 1st November 2011: Assistant Professor of Catania University – Faculty of Medicine and Surgery, Department G.F. Ingrassia

From 1st November 2014: Assistant Professor of Catania University – School of Medicine, Department of Biomedical Sciences and Biotechnology

ARTICLES
Barbagallo D, Condorelli AG, Ragusa M, Salito L, Sammito M, Banelli B, Caltabiano R, Barbagallo GM, Zappalà A, Battaglia R, Cirnigliaro M, Lanzafame S, Vasquez E, Parenti R, Cicirata F, Pietro CD, Romani M, Purrello M. Dysregulated miR-671-5p / CDR1-AS / CDR1 / VSNL1 axis is involved in glioblastoma multiforme. Oncotarget. 2015 Dec 15.
Matà R, Palladino C, Nicolosi ML, Presti AR, Malaguarnera R, Ragusa M, Sciortino D, Morrione A, Maggiolini M, Vella V, Belfiore A. IGF-I induces upregulation of DDR1 collagen receptor in breast cancer cells by suppressing MIR-199a-5p through the PI3K/AKT pathway. Oncotarget. 2015 Dec 9.
Ragusa M, Barbagallo C, Statello L, Condorelli AG, Battaglia R, Tamburello L, Barbagallo D, Di Pietro C, Purrello M. Non-coding landscapes of colorectal cancer. World J Gastroenterol. 2015 Nov 7;21(41):11709-39.
Rizzo R, Ragusa M, Barbagallo C, Sammito M, Gulisano M, Calì PV, Pappalardo C, Barchitta M, Granata M, Condorelli AG, Barbagallo D, Scalia M, Agodi A, Di Pietro C, Purrello M. Circulating miRNAs profiles in tourette syndrome: molecular data and clinical implications. Mol Brain. 2015 Jul 25;8(1):44.
Ragusa M, Barbagallo C, Statello L, Caltabiano R, Russo A, Puzzo L, Avitabile T, Longo A, Toro MD, Barbagallo D, Valadi H, Di Pietro C, Purrello M, Reibaldi M. miRNA profiling in vitreous humor, vitreal exosomes and serum from uveal melanoma patients: Pathological and diagnostic implications. Cancer Biol Ther. 2015 May 7:0.
Ragusa M, Barbagallo D, Purrello M. Exosomes: nanoshuttles to the future of BioMedicine. Cell Cycle. 2015;14(3):289-90.
Santonocito M, Vento M, Guglielmino MR, Battaglia R, Wahlgren J, Ragusa M, Barbagallo D, Borzì P, Rizzari S, Maugeri M, Scollo P, Tatone C, Valadi H, Purrello M, Di Pietro C. Molecular characterization of exosomes and their microRNA cargo in human follicular fluid: bioinformatic analysis reveals that exosomal microRNAs control pathways involved in follicular maturation. Fertil Steril. 2014 Sep 17. pii: S0015-0282(14)02064-0.
Barbagallo D, Condorelli AG, Piro S, Parrinello N, Fløyel T, Ragusa M, Rabuazzo AM, Størling J, Purrello F, Di Pietro C, Purrello M. CEBPA exerts a specific and biologically important proapoptotic role in pancreatic β cells through its downstream network targets. Mol Biol Cell. 2014 Aug 15;25(16):2333-41.
Vallelunga A, Ragusa M, Di Mauro S, Iannitti T, Pilleri M, Biundo R, Weis L, Di Pietro C, De Iuliis A, Nicoletti A, Zappia M, Purrello M, Antonini A. Identification of circulating microRNAs for the differential diagnosis of Parkinson's disease and Multiple System Atrophy. Front Cell Neurosci. 2014 Jun 10;8:156.
Ragusa M, Statello L, Maugeri M, Barbagallo C, Passanisi R, Alhamdani M, Li Destri G, Cappellani A, Barbagallo D, Scalia M, Valadi H, Hoheisel J, Di Pietro C, Purrello M. Highly skewed distribution of miRNAs and proteins between CRC cells and their exosomes following Cetuximab treatment: biomolecular, genetic and translational implications. Oncoscience. 2014, published on line 16.03.14.
Ragusa M, Caltabiano R, Russo A, Puzzo L, Avitabile T, Longo A, Toro MD, Di Pietro C, Purrello M, Reibaldi M. MicroRNAs in vitreus humor from patients with ocular diseases. Mol Vis. 2013;19:430-40.
Barbagallo D, Piro S, Condorelli AG, Mascali LG, Urbano F, Parrinello N, Monello A, Statello L, Ragusa M, Rabuazzo AM, Pietro C, Purrello F, Purrello M. miR-296-3p, miR-298-5p and their downstream networks are causally involved in the higher resistance of mammalian pancreatic alpha cells to cytokine-induced apoptosis as compared to beta cells. BMC Genomics. 2013 Jan 29;14(1):62.
Di Pietro C, Cicinelli E, Guglielmino MR, Ragusa M, Farina M, Palumbo MA, Cianci A. Altered Transcriptional Regulation of Cytokines, Growth Factors, and Apoptotic Proteins in the Endometrium of Infertile Women with Chronic Endometritis. Am J Reprod Immunol. 2013 Jan 28. [Epub ahead of print]
Santonocito M, Guglielmino MR, Vento M, Ragusa M, Barbagallo D, Borzì P, Casciano I, Scollo P, Romani M, Tatone C, Purrello M, Di Pietro C. The apoptotic transcriptome of the human MII oocyte: characterization and age-related changes. Apoptosis. 2013 Feb;18(2):201-11.
Ragusa M, Statello L, Maugeri M, Majorana A, Barbagallo D, Salito L, Sammito M, Santonocito M, Angelica R, Cavallaro A, Scalia M, Caltabiano R, Privitera G, Biondi A, Di Vita M, Cappellani A, Vasquez E, Lanzafame S, Tendi E, Celeste S, Di Pietro C, Basile F, Purrello M. Specific alterations of the microRNA transcriptome and global network structure in colorectal cancer after treatment with MAPK/ERK inhibitors. J Mol Med (Berl). 2012 Dec;90(12):1421-38.
Guglielmino MR, Santonocito M, Vento M, Ragusa M, Barbagallo D, Borzì P, Casciano I, Banelli B, Barbieri O, Astigiano S, Scollo P, Romani M, Purrello M, Di Pietro C. TAp73 is downregulated in oocytes from women of advanced reproductive age. Cell Cycle. 2011 Oct 1;10(19):3253-6.
Ragusa M, Majorana A, Statello L, Maugeri M, Salito L, Barbagallo D, Guglielmino MR, Duro LR, Angelica R,  Caltabiano R, Biondi A, Di Vita M, Privitera G, Scalia M, Cappellani A, Vasquez E, Lanzafame S, Basile F, Di Pietro C, Purrello M. Specific alterations of microRNA transcriptome and global network structure in colorectal carcinoma after cetuximab treatment. MOLECULAR CANCER THERAPEUTICS. 2010 Dec;9(12):3396-409.
Ragusa M, Avola G, Angelica R, Barbagallo D, Guglielmino MR, Duro LR, Majorana A, Statello L, Salito L, Consoli C, Camuglia MG, Di Pietro C, Milone G, Purrello M. Expression profile and specific network features of the Apoptotic Machinery explain relapse of Acute Myeloid Leukemia after chemotherapy. BMC CANCER. 2010 Jul 19;10:377.
Ragusa M, Majorana A, Banelli D, Barbagallo D, Statello L, Casciano I, Guglielmino MR, Duro LR, Scalia M, Magro G, Di Pietro C, Romani M, Purrello M. MIR152, MIR200B, MIR338, human positional and functional Neuroblastoma candidates, are involved in neuroblast differentiation and apoptosis. JOURNAL OF MOLECULAR MEDICINE. 2010 Oct;88(10):1041-53. Epub 2010 Jun 25.
Di Pietro C, Vento M, Guglielmino MR, Borzì P, Santonocito M, Ragusa M., Barbagallo D, Duro LR, Majorana A, De Palma A, Garofalo MR, Minutolo E, Scollo P, Purrello M. Molecular profiling of human oocytes after vitrification strongly suggests that they are biologically comparable to freshly isolated gametes. FERTILITY AND STERILITY. 2010 Jun 8. [Epub ahead of print]
Di Pietro C, Ragusa M., Barbagallo D, Duro L, Guglielmino MR, Majorana A, Angelica R, Scalia M, Statello L, Salito L, Tomasello L, Pernagallo S, Valenti S, D’Agostino V, Triberio P, Tandurella I, Palumbo GA, La Cava P, Cafiso V, Li Destri G, Lanzafame S, Bertuccio T, Santagati M, Di Raimondo F, Stefani S, Mishra B, Purrello M. The Apoptotic Machinery As A Biological Complex System: Analysis of its Omics and Evolution, Identification of Candidate Genes for Fourteen Major Types of Cancer and Experimental Validation in CML and Neuroblastoma. BMC MEDICAL GENOMICS. 2009 Apr 30;2:20.

Di Pietro C, Ragusa M., Barbagallo D, Duro LR, Guglielmino MR, Majorana A, Giunta V, Rapisarda A, Tricarichi E, Miceli M, Angelica R, Grillo A, Banelli B, Defferari I, Forte S, Laganà A, Bosco C, Giugno R, Pulvirenti A, Ferro A, Grzeschik KH, Di Cataldo A, Tonini GP, Romani M, Purrello M. Involvement of GTA protein NC2beta in Neuroblastoma pathogenesis suggests that it physiologically participates in the regulation of cell proliferation. MOLECULAR CANCER. 2008 Jun 6;7:52.

Di Pietro C, Vento M, Ragusa M., Barbagallo D, Guglielmino MR, Maniscalchi T, Duro LR, Tomasello L, Majorana A, De Palma A, Borzì P, Scollo P, Purrello M. Expression analysis of TFIID in single human oocytes. New potential molecular markers of oocyte quality. REPRODUCTIVE BIOMEDICINE ONLINE. 2008 Sep;17(3):338-49.
Ferro A, Giugno R, Pigola G, Pulvirenti A, Di Pietro C, Purrello M, Ragusa M. Sequence similarity is more relevant than species specificity in probabilistic backtranslation. BMC BIOINFORMATICS. 2007 Feb 21;8:58.
Di Pietro C, Ragusa M., Duro L, Guglielmino MR, Barbagallo D, Carnemolla A, Laganà A, Buffa P, Angelica R, Rinaldi A, Calafato MS, Milicia I, Caserta C, Giugno R, Pulvirenti A, Giunta V, Rapisarda A, Di Pietro V, Grillo A, Messina A, Ferro A, Grzeschik KH, Purrello M. Genomics, Evolution and Expression of TBPL2, a Member of the TBP Family. DNA AND CELL BIOLOGY. 2007 Jun;26(6):369-85.
Di Pietro C, Piro S, Tabbì G, Ragusa M., Di Pietro V, Zimmitti V, Anello M, Consoli U, Trovato Salinaro E, Caruso M, Vancheri C, Crimi N, Sabini Mg, Cirrone GAP, Raffaele L, Privitera G, Pulvirenti A, Giugno R, Ferro A, Cuttone G, Lo Nigro S, Purrello R, Purrello F, Purrello M. Cellular And Molecular Effects Of Protons: Apoptosis Induction And Potential Implications For Cancer Therapy. APOPTOSIS. 2006 Jan;11(1):57-66
Purrello M, Di Pietro C, Ragusa M., Pulvirenti A, Giugno R, Di Pietro V, Emmanuele G, Travali S, Scalia M, Shasha D, Ferro A. In vitro and in silico cloning of Xenopus laevis SOD2 and its phylogenetic analysis. DNA AND CELL BIOLOGY. 2005 Feb;24(2):111-6.
Scalia M, Di Pietro C, Poma M, Ragusa M., Sichel G, Corsaro C. The Spleen Pigment Cells in Some Amphibia. PIGMENT CELL RESEARCH. 2004 Apr;17(2):119-27.

ABSTRACTS

A Vallelunga and RAGUSA M. and S Di Mauro and T Iannitti and M Pilleri and R Biundo and L Weis and C Di Pietro and M Zappia and M Purrello and A Antonini. Identification of circulating microRNAs for the differential diagnosis of Parkinson’s disease and Multiple System Atrophy. XX World Congress on Parkinson's Disease and Related Disorders. Geneva, Switzerland, december 8-11, 2013.

B Banelli and RAGUSA M. and M Maugeri and G Allemanni and A Forlani and C Di Pietro and M Purrello and M Romani M and F Parodi. Epigenetic alteration of the cross talk genes-miRNAs in high risk Neuroblastoma. Cell Symposia. Melià, Sitges, Spain, october 6-8, 2013.

D Barbagallo and S Piro and A G Condorelli and L G Mascali and F Urbano and N Parrinello and A Monello and L Statello and RAGUSA M. and A M Rabuazzo and C Di Pietro and F Purrello and M Purrello. miR-296-3p, miR-298-5p and their downstream networks are causally involved in the higher resistance of mammalian pancreatic α cells to cytokine-induced apoptosis as compared to b cells. Oral communication. XV Congresso Nazionale AIBG. Arcavacata di Rende (CS), 27-28 settembre 2013.

B Banelli and RAGUSA M. and M Maugeri and G Allemanni and A Forlani and C Di Pietro and M Purrello and M Romani M and F Parodi. Epigenetic alteration of the cross-talk genes-miRNAs in high risk Neuroblastoma. 55th SIC Annual Meeting. Catanzaro, 23-26 settembre.

M Ragusa, L Statello, M Maugeri, A Majorana, D Barbagallo, L Salito, M Sammito, M Santonocito, R Angelica, A Cavallaro, M Scalia, R Caltabiano, G Privitera, A Biondi, M Di Vita, A Cappellani, E Vasquez, S Lanzafame, E Tendi, S Celeste, C Di Pietro, F Basile, M Purrello. Specific alterations of The microRNA transcriptome and global network structure in colorectal cancer after treatment with MAPK/ERK inhibitors. Oral communication. XIV Congresso Nazionale AIBG. Perugia (Italia), 28-29 settembre 2012.

M Ragusa, L Statello, M Maugeri, A Majorana, D Barbagallo, L Salito, M Sammito, M Santonocito, R Angelica, A Cavallaro, M Scalia, R Caltabiano, G Privitera, A Biondi, M Di Vita, A Cappellani, E Vasquez, S Lanzafame, E Tendi, S Celeste, C Di Pietro, F Basile, M Purrello. Specific alterations of the microRNA transcriptome and global network structure in colorectal cancer after treatment with MAPK/ERK inhibitors. Oral communication. International Workshop on Small RNA in Cancer, Inflammation, and Aging. Copenhagen, Denmark. 3-4 September 2012.

M Ragusa, A Majorana, L Statello, L Salito, D Barbagallo, MR Guglielmino, LR Duro, R Angelica,  R Caltabiano, A Biondi, M Di Vita, G Privitera, A Cappellani, E Vasquez, S Lanzafame, F Basile, C Di Pietro, M Purrello. Specific alterations of microRNA transcriptome and global network structure in colorectal carcinoma after cetuximab treatment. Oral communication. XII Congresso Nazionale AIBG. Trento (Italia), 08-09 ottobre 2010.

D Barbagallo, S Piro, M Ragusa, LR Duro, ET Maniscalchi, A Majorana, LG Mascali, MR Guglielmino, A Monello, AM Rabuazzo, C Di Pietro, F Purrello, M Purrello. A molecular Systems Medicine approach to Diabetes Mellitus pinpoints the molecular bases of the higher resistance to cytokine-induced apoptosis of mammalian pancreas a cells respect to β cells. XII Congresso Nazionale AIBG. Trento (Italia), 08-09 ottobre 2010.

C Di Pietro C, MR Guglielmino, M Vento,  P Borzì, M Santonocito, M Ragusa, D Barbagallo, LR Duro, A Majorana, P Scollo, M Purrello. Molecular profiling of human oocytes after vitrification strongly suggests that they are biologically comparable to freshly isolated gametes. XII Congresso Nazionale AIBG. Trento (Italia), 08-09 ottobre 2010.

D Barbagallo, S Piro, M Ragusa, LR Duro, T Maniscalchi, A Majorana, L Mascali, MR Guglielmino, A Monello, MA Rabuazzo, C Di Pietro, F Purrello, M Purrello. A Molecular Systems BioMedicine Approach to Diabetes: Characterization, Prioritization and Network Analysis of New Candidate Genes from the Apoptotic Machinery. The EMBO Meeting 2010. Barcellona, Spain, 4-7 september 2010.

M Ragusa, A Majorana, L Statello, L Salito, D Barbagallo, MR Guglielmino, LR Duro, R Angelica,  R Caltabiano, A Biondi, M Di Vita, G Privitera, A Cappellani, E Vasquez, S Lanzafame, F Basile, C Di Pietro, M Purrello. Specific alterations of microRNA transcriptome and global network structure in colorectal carcinoma after cetuximab treatment. Poster. The EMBO Meeting 2010. Barcellona, Spain, 4-7 september 2010.

D Barbagallo, S Piro, M Ragusa, LR Duro, T Maniscalchi, A Majorana, L Mascali, MR Guglielmino, A Monello, MA Rabuazzo, C Di Pietro, F Purrello, M Purrello. A Molecular Systems BioMedicine Approach to Diabetes: Characterization, Prioritization and Network Analysis of New Candidate Genes from the Apoptotic Machinery. 4th ESF Conference on Functional Genomics and Disease. Dresden, Germany, 14-17 April 2010.

M Ragusa, A Majorana, L Statello, L Salito, D Barbagallo, MR Guglielmino, LR Duro, R Angelica,  R Caltabiano, A Biondi, M De Vita, G Privitera, A Cappellani, E Vasquez, S Lanzafame, F Basile, C Di Pietro, M Purrello. MicroRNA expression profile and network in colorectal carcinoma after chemotherapy. 4th ESF Conference on Functional Genomics and Disease. Dresden, Germany, 14-17 April 2010.

M Santonocito, MR Guglielmino, M Vento, P Borzì, M Ragusa, D Barbagallo, A De Palma, MR Garofalo, E Minutolo, P Scollo, M Purrello, C Di Pietro. Identification and Validation of Molecular Markers of Human Oocyte Biological Quality After Vitrification. Oral communication. 14th World Congress of Gynecological Endocrinology. Firenze, Italy, 4-7 March 2010.

MR Guglielmino, M Vento, P Borzì, M Santonocito, M Ragusa, D Barbagallo, A De Palma, MR Garofalo, E Minutolo, P Scollo, C Di Pietro, M Purrello. Apoptotic Machinery and Aging: Gene Expression Profiles in Oocytes and Cumulus Cells by High Throughput Real Time PCR. Oral communication. 14th World Congress of Gynecological Endocrinology. Firenze, Italy, 4-7 March 2010.

D Barbagallo, S Piro, M Ragusa, LR Duro, A Majorana, T Maniscalchi, A Monello, C Di Pietro, MA Rabuazzo, F Purrello, M Purrello. A Phatogenomics of the Human Apoptotic Machinery: Identification of New Candidate Genes for Diabetes. XI Congresso Nazionale AIBG. Palermo (Italia), 08/10 ottobre 2009.

C Di Pietro, M Vento, MR Guglielmino, M Santonocito, M Ragusa, D Barbagallo P, Borzì, P Scollo, M Scalia, and M Purrello. Valutazione Della Qualita’ Ovocitaria Mediante Profili  Di  Espressione Genica Nelle Singole Cellule. Oral communication. XI Congresso Nazionale AIBG. Palermo (Italia), 08/10 ottobre 2009.

M Ragusa, A Majorana, B Banelli, D Barbagallo, L Statello, L Salito, R Angelica, MR Guglielmino, LR Duro, C Di Pietro, M  Romani, M Purrello. Mir152, Mir200b, Mir338, Involved In Neuronal Differentiation And Apoptosis, Are Positional And Functional Neuroblastoma Candidates. XI Congresso Nazionale AIBG. Palermo (Italia), 08/10 ottobre 2009.

C Di Pietro, MR Guglielmino, M Vento, P Borzì, M Ragusa, D Barbagallo, M Santonocito, A De Palma, MR Garofalo, P Scollo and M Purrello. Analisi dopo vitrificazione di marcatori molecolari di qualità ovocitaria. I° Congresso Unificato delle Società Italiane di Medicina della Riproduzione “I GAMETI”. Poster Riccione (Italy), 28/30 may 2009.

M Vento, MR Guglielmino, C Di Pietro, P Borzì, V Spina, M Santonocito, S Giliberto, A De Palma, MR Garofalo, G Poma, M Purrello and P Scollo. A Pilot Study On The Usefulness Of Antioxidant Therapy On Follicular Microenvironment. 13th World Congress on Human Reproduction. Venezia (Italy), 5-8 March 2009.

C Di Pietro, M Ragusa, D Barbagallo, LR Duro, MR Guglielmino, A Majorana, R Angelica, L Statello, L Tomasello, M Scalia, S Pernagallo, S Valenti, V Dagostino, P Triberio, I Tandurella, G Palumbo, V Cafiso, R Giugno, G Li Destri, S Lanzafame, M Santagati, F Di Raimondo, S Stefani, M Purrello. The Apoptotic Machinery As A Biological Complex System: Analysis of its Omics and Evolution, Identification of Candidate Genes for Fourteen Types of Cancer and Experimental Validation in CML and Neuroblastoma. Keystone Symposia: Omics Meets Cell Biology. Breckenridge, Colorado. January 25-30 2009.

M Ragusa, A Majorana, D Barbagallo, LR Duro, MR Guglielmino, L Statello, L Tomasello , ML Fragala’, C Di Pietro,  M Purrello. MIRN152, MIRN200B and MIRN338, positional NB candidates, are involved in neuronal differentiation and apoptosis. Oral communication. XI Congresso Nazionale SIGU. Genova – Italy, 23 – 25 october 2008.

C Di Pietro, M Ragusa, D Barbagallo, LR Duro, MR Guglielmino, A Majorana, R Angelica, M Scalia, L Statello, L Tomasello, S Pernagallo, S Valenti, V Dagostino, P Triberio, I Tandurella, G Palumbo, V Cafiso, G Li Destri, S Lanzafame, M Santagati, F Di Raimondo, S Stefani, B Mishra, M Purrello. The Apoptotic Machinery As A Biological Complex System: Analysis of its Omics and Evolution, Identification of Candidate Genes for Fourteen Types of Cancer and Experimental Validation in CML and Neuroblastoma. XI Congresso Nazionale SIGU. Genova – Italy, 23 – 25 october 2008.

C Di Pietro, M Vento, M Ragusa, D Barbagallo, MR Guglielmino, T Maniscalchi, LR Duro, L Tomasello, A Majorana, A De Palma, P Borzì, P Scollo And M Purrello. Molecular markers of oocyte quality. XI Congresso Nazionale SIGU. Genova – Italy, 23 – 25 october 2008.

C Di Pietro, M Ragusa, D Barbagallo, LR Duro, MR Guglielmino, A Majorana A, R Angelica, M Scalia, L Statello, L Tomasello, S Pernagallo, S Valenti, V Dagostino, P Triberio, I Tandurella, G Palumbo, V Cafiso, G Li Destri, S Lanzafame, M Santagati, F Di Raimondo, S Stefani, B Mishra, M Purrello. The Apoptotic Machinery As A Biological Complex System: Analysis of its Omics and Evolution, Identification of Candidate Genes for Fourteen Types of Cancer and Experimental Validation in CML and Neuroblastoma. EMBO Conference From Functional Genomics to Systems Biology. Heidelberg- Germany, 15 – 18 october 2008.

C Di Pietro, M Ragusa, D Barbagallo, LR Duro, MR Guglielmino, A Majorana, R Angelica, S Pernagallo, S Valenti, V D’Agostino, P Triberio, L Statello, L Tomasello, R Giugno, G Palumbo, G Li Destri, S Lanzafame, F Di Raimondo, S Stefani, M Purrello. The Apoptotic Machinery As A Biological Complex System: Analysis of its Omics, Identification of Candidate Genes for Fourteen Major Types of Cancer and Experimental Validation in CML and Neuroblastoma. 3rd EFS Functional Genomics Conference. Innsbruck, Austria, 1 – 4 october 2008.

M Ragusa, D Barbagallo, L Duro, MR Guglielmino, Alessandra Majorana, R Angelica, L Mascali, Statello, A Iachella, L Salito,  L Tomasello, ML  Fragalà, N Torrisi, C Di Pietro, M Purrello. Involvement of miR-152, miR-200b, miR-338 in Neuroblastoma pathogenesis suggests their possible role in cell proliferation and neuronal differentiation. Oral communication. X National Biotechnology Congress. Perugia. 17 - 19 September 2008.

C Di Pietro, M Ragusa, D Barbagallo,  LR Duro, MR Guglielmino, A Majorana, R Angelica, L Statello, L Tomasello, S Pernagallo, S Valenti, V D’Agostino, P Triberio, I Tandurella, S Forte, A Laganà, C Bosco, R Di Natale, R Giugno, A Pulvirenti, A Ferro, G Palumbo, G Li Destri,  S Lanzafame, V Cafiso, T Bertuccio, M  Santagati, F Di  Raimondo, S Stefani, M Purrello.  The Apoptotic Machinery As A Biological Complex System: Analysis Of Its Omics And Evolution, Identification Of Candidate Genes For Fourteen Major Types Of Cancer And Experimental Validation in  CML And Neuroblastoma. Oral communication. 10th Experimental Chaos Conference. Catania 3 – 6 June 2008.

M Farina, C Di Pietro, A Cacciatore, MR Guglielmino, M Ragusa, MA Palumbo, A Cianci. Evaluation of Endometrial Quality in Reproductive Medicine: The Role of Endometrial Inflammation Pathology. 13th World Congress of Gynecological Endocrinology, Florence 28 feb – 2 mar 2008.

C Di Pietro, M Vento, M Ragusa, D Barbagallo, MR Guglielmino, T Maniscalchi, LR Duro, L Tomasello, A Majorana, A De Palma, P Borzì, P Scollo, M Purrello. Molecular Markers of Oocyte Quality. 13th World Congress of Gynecological Endocrinology, Florence 28 feb – 2 mar 2008.
 
C Di Pietro, M Vento, M Ragusa, D Barbagallo, MR Guglielmino, T Maniscalchi, LR Duro, L Tomasello, P Borzì, P Scollo and M Purrello. Analysis of genes expression in single human oocytes: Search of molecular markers related to oocytes quality. 14th World Congress on IVF & 3rd World Congress on IVM – Montreal, September 15-19, 2007.

A Ferro, S Forte, R Giugno, A Laganà, A Pulvirenti, D Barbagallo, C Di Pietro,  A Majorana, M Purrello, M Ragusa, D Bonci, R De Maria, A Pagliuca. Prediction of human targets for viral encoded microRNAs by thermodynamics and empirical constraints. Oral communication. Italian Bioinformatics Society (BITS) 2007, Napoli 26 – 28 april 2007. 

C Di Pietro, M Ragusa, L Duro, V D’Agostino, P Triberio, D Barbagallo, A Di Cataldo, G Li Destri, A Laganà, S Forte, S Pernagallo, S Valenti, MR Guglielmino, T Maniscalchi, R Giugno, A Pulvirenti, M Santagati, G Russo, M Scalia, R Bernardini, L Pavone, S Stefani, A Ferro, KH Grzeschik, M Purrello. The Apoptotic Machinery As A Biological Complex System: An Omics Analysis and Identification of Candidate Genes for Breast Adenocarcinoma, Thyroid Carcinoma and Neuroblastoma. Oral communication. XI Congresso della Associazione Italiana di Biologia e Genetica generale e molecolare (AIBG), Massa Lubrense 11-14 september 2006.

C Di Pietro, M Ragusa, L Duro, V D’Agostino, P Triberio, D Barbagallo, A Di Cataldo, Li Destri, A Laganà, S Forte, S Pernagallo1, S Valenti, M R Guglielmino, T Maniscalchi, R Giugno, A Pulvirenti, M Santagati, G Russo, M Scalia, R Bernardini, S Guccione, L Pavone, S Stefani, A Ferro, K H Grzeschik, M Purrello. Complex Systems Biology: Structural, Functional and Pathological Genomics of the Apoptotic Machinery and Identification of Candidate Genes for Breast Adenocarcinoma, Thyroid Carcinoma and Neuroblastoma. Oral communication. VIII Congresso SIMAI Baia Samuele (Ragusa),  22-26 May 2006.

R Giugno, D Skripin, A Pulvirenti, G Pigola, D Reforgiato, M Ragusa, C Di Pietro, S Guccione, M Purrello, D Shasha, A Ferro. GraphBlast: A Fast and Universal Method for Querying Graphs. World Pharmaceutical Congress, May 23–25 2006, Pennsylvania Convention Center – Philadenphia, PA.

C Di Pietro, M Ragusa, A Laganà, D Barbagallo, I Tandurella, L Duro, R Giugno, A Pulvirenti, S Pernagallo, S Valenti, M S Calafato, V Di Pietro, M R Guglielmino, R Angelica, Cinzia Caserta, M Santagati, R Bernardini, L Pavone, S Stefani, A Ferro, M Purrello. Genomica Strutturale e Funzionale del Macchinario Apoptotico: Identificazione di Geni Candidati per Malattie Genetiche Degenerative. VIII Congresso della Associazione Italiana di Biologia e Genetica generale e molecolare (AIBG), Ancona 15-18 september 2005

C Di Pietro, M Ragusa, M S Calafato, C Caserta, A Carnemolla, M R Guglielmino, D Barbagallo, R Angelica,  A Grillo, L Duro,   I Tandurella, V Giunta, M Scalia, M Vento,  P Buffa, A Messina, A Laganà, R Giugno,  A Pulvirenti, K H Grzeschik, R  Roeder, A Ferro, M Purrello. Genomica Strutturale e Funzionale dell’Apparato Generale di Trascrizione:  Espressione Tessuto-Specifica dei GTF Negli Ovociti. VIII Congresso della Associazione Italiana di Biologia e Genetica generale e molecolare (AIBG), Ancona 15-18 september 2005

R Giugno, A Pulvirenti, M Ragusa, L Facciolà, L Patelmo, V Di Pietro, C Di Pietro, M Purrello, A Ferro. Local sensitive backtranslation based on multiple sequenze alignment. Oral communication. IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology October 7 - October 8. La Jolla, California,USA. 2004.

C Di Pietro, M Ragusa, A Carnemolla, V Di Pietro, R Giugno, A Pulvirenti, A Ferro, A. Grillo, A. Messina, K H Grzeschik, M Purrello. Struttura genomica, espressione ed evoluzione di TPG, un nuovo membro della famiglia TBP. VII Congresso AIBG (Associazione Italiana di Biologia e Genetica Generale e Molecolare) Grado (GO), 23 – 26 september 2004.

V Di Pietro, M Ragusa, A Carnemolla, I Tandurella, R Giugno, A Pulvirenti, A Ferro, S Stefani, A Messina, C Di Pietro, M Purrello. Genomica Strutturale e Funzionale del Macchinario Apoptotico: identificazione di nuovi geni candidati per il Morbo di Parkinson. VII Congresso AIBG (Associazione Italiana di Biologia e Genetica Generale e Molecolare) Grado (GO), 23 – 26 september 2004.

C Di Pietro, M Ragusa, A Carnemolla, V Di Pietro, R Giugno, A Pulvirenti, A Ferro, K H Grzeschik, M Purrello.  Structure, Expression and Evolution of TPG, a New  Member of the TBP Family. Oral communication. 7° Congresso Nazionale delle Biotecnologie, Catania, september 2004.

C Di Pietro, A Ferro, R Giugno, A Laganà, G Pigola, A Pulvirenti, M Purrello,. M. Ragusa. Anticlustal: Multiple Sequence Alignment by Antipole Clustering. Oral communication. 7° Congresso Nazionale delle Biotecnologie, Catania, september 2004.

R Giugno, A Pulvirenti, M. Ragusa, L Facciolà, L Patelmo, V Di Pietro, C Di Pietro, M Purrello, A Ferro. Local sensitive backtranslation based on multiple sequence alignment. Oral communication. 7° Congresso Nazionale delle Biotecnologie, Catania, september 2004.

C Di Pietro, M Ragusa, A Carnemolla, V Di Pietro, R Giugno, A Pulvirenti, A Ferro, K H Grzeschik, M Purrello.  Structure, Expression and Evolution of TPG, a New  Member of the TBP Family. International School of Advanced BioMedicine and BioInformatics. Lipari  (Me), may 29 - june 5, 2004.

M Ragusa, C Di Pietro, V Di Pietro, I Tandurella, M Scalia, A Ferro, A Giugno, A Pulvirenti, S Pernagallo, S Valenti, S Stefani, A Messina, M Purrello. Structural and Functional Genomics of the Apoptotic Machinery. International School of Advanced BioMedicine and BioInformatics. Lipari  (Me), may 29 - june 5, 2004.

C Di Pietro, S Piro, G Tabbì, V Zimmitti, V Di Pietro, M Ragusa, M Anello, E Trovato  Salinaro, C Vancheri, N Crimi, M G Sabini, G A P Cirrone, L Raffaele, G Privitera,  G Cuttone, S Lo Nigro, R Purrello, F Purrello, M Purrello. Specific induction of apoptosis in human cells by proton beams suggests innovative anticancer strategies. Oral communication. Impact of Biotechnology on Predictive Oncology and Intervention Strategies. Nice, february 2004.

C Di Pietro, M Ragusa, A Pulvirenti, R Giugno, E Modica,  A Rapisarda, V Giunta, G Pigola, V Zimmitti, V Di Pietro, A Messina, KH Grzeschik, R Roeder, A Ferro, M Purrello.  Identificazione ed analisi evolutiva di THG, un gene umano con elevata omologia  a TBP, mediante un approccio combinato di Biologia sperimentale e di Biologia computazionale. VI Congresso Nazionale AIBG (Associazione Italiana di Biologia e Genetica), 2003, Giardini Naxos (ME).

C Di Pietro, S Piro, G Tabbì, V Zimmitti, V Di Pietro, M Ragusa, M Anello, E Trovato Salinaro, C Vancheri, N Crimi, MG Sabini, GAP Cirrone, L Raffaele, G Privitera, G Cuttone, S  Lo Nigro, R Purrello, F Purrello, M Purrello. L’induzione di apoptosi da parte di protoni suggerisce innovative strategie terapeutiche anticancro. VI Congresso Nazionale AIBG (Associazione Italiana di Biologia e Genetica), 2003, Giardini Naxos (ME).

M Purrello, C Di Pietro, M Ragusa, A Pulvirenti, G Pigola, R Giugno, E Modica, V Zimmitti, V Di Pietro, T Maugeri, G Emmanuele, S Travali, M Scalia, D Shasha, A Ferro. La clonazione in vitro ed in silico di SOD2 di Xenopus laevis e la sua analisi evolutiva   mediante AntiClustAl, un nuovo programma per l’allineamento multiplo, dimostrano un’elevata conservazione della sua sequenza aminoacidica durante l’evoluzione. VI Congresso Nazionale AIBG (Associazione Italiana di Biologia e Genetica), 2003, Giardini Naxos (ME).

C Di Pietro, V Di Pietro, G Emmanuele, A Ferro, T Maugeri, E Modica, G Pigola, A  Pulvirenti, M Purrello, M Ragusa, M Scalia, D Shasha, S Travali, V Zimmitti. ANTICLUSTAL: Multiple Sequence Alignment by Antipole Clustering and Linear  Approximate 1-Median Computation. PROC IEEE COMPUTER SOCIETY BIOINFORMATICS CONFERENCE, CSB 2003 Standford.

V Zimmitti, S Piro, G Tabbì, C Di Pietro, V Di Pietro, M Ragusa, M Anello, E Trovato Salinaro, C Vancheri, N Crimi, M G Sabini, G A P Cirrone, L Raffaele, G Privitera, G Cuttone, S Lo Nigro, R Purrello, F Purrello, M Purrello. Specific induction of apoptosis in human cells by proton beams suggests innovative anticancer strategies. Oral communication. 20th IATMO Conference Tumour markers in  cancer diagnosis and therapy. Siena, Italy, june 21-25 2003.

C Di Pietro, S Piro, G Tabbì, V Zimmitti, V Di Pietro, M Ragusa, M Anello,  E Trovato Salinaro, C Vancheri, N Crimi, MG Sabini, GAP Cirrone, L Raffaele, G Privitera, G Cuttone, S Lo Nigro, R Purrello, F Purrello, M Purrello. Specific induction of apoptosis in human cells by proton beams suggests innovative anticancer strategies. 6° Congresso Nazionale Biotecnologie. Padova, 4 – 6 june 2003.

M Purrello, C Di Pietro, M Ragusa, A Pulvirenti, G Pigola, E Modica, V Zimmitti, V Di Pietro, T Maugeri, G Emmanuele, S Travali, M Scalia, D Shasha, A Ferro. In vitro and in silico cloning of Xenopus laevis SOD2 demonstrates very high amino acid sequence conservation during evolution. 6° Congresso Nazionale Biotecnologie. Padova, 4 – 6 june 2003.

M Purrello, C Di Pietro, M Ragusa, A Pulvirenti, G Pigola, E Modica, T Maugeri, G Emmanuele, S Travali, M Scalia, D Shasha, A Ferro. In vitro and in silico cloning of Xenopus laevis SOD2 demonstrates very high aminoacid sequence conservation during  evolution. First European Conference: Functional Genomics and Disease. Prague, 14-17 may 2003.

A Rapisarda, C Di Pietro, V Ucciardello, V Giunta, M Ragusa, V Di Pietro, M Romani, G Tonini, G Sichel, M Purrello.  Il gene per la subunità β del fattore globale di repressione della trascrizione NC2 è represso nel neuroblastoma”. III Congresso Nazionale S.I.G.U. Orvieto (Italy) 2001.

CHAPTERS OF BOOKS

M RAGUSA, A GAROFALO, C MONTONERI. Diagnosi Prenatale e Genetica di Sailesh Kumar. In: DEWHURST - Trattato di Ostetricia e Ginecologia. 99 – 108. Ed. D. Keith Edmonds, EMSI (Edizioni Mediche Scientifiche Internazionali); 2012.

C DI PIETRO, M VENTO, RAGUSA M., D BARBAGALLO, MR GUGLIELMINO, T MANISCALCHI, LR DURO, L TOMASELLO, P BORZÌ, P SCOLLO AND M PURRELLO (2007). TAF4B is a molecular marker of oocyte quality. In: AUTORI VARI. 14th World Congress on In Vitro Fertilization & 3rd World Congress on In Vitro Maturation. p. 81-85, BOLOGNA: Ed Lin Tan, Gomel, Gosden, Tulandi, Medimond S.r.l

DI PIETRO C, FERRO A., PIGOLA G, PULVIRENTI A, PURRELLO M, RAGUSA M., SHASHA D (2005). ANTICLUSTAL: Multiple Sequence Alignment by Antipole Clustering. In: WANG, ZAKI, TOIVONEN, SHASHA. Data Mining in Bioinformatics. p. 43-57, LONDON: Springer Verlag

PUBLISHED SEQUENCES IN GENBANK

AY362041             
Xenopus laevis manganese superoxide dismutase mRNA, complete cds
gi|34305124|gb|AY362041.1|[34305124]

BK005772             
TPA_inf: Pan troglodytes chromosome 15 TATA box binding protein-like 2 mRNA, complete cds
gi|148910842|tpg|BK005772.1|[148910842]

BK005773             
TPA_inf: Mus musculus chromosome 2 TATA box binding protein-like 2 mRNA, complete cds
gi|148910844|tpg|BK005773.1|[148910844]

BK005774             
TPA_inf: Rattus norvegicus chromosome 3 TATA box binding protein-like 2 mRNA, complete cds
gi|148910846|tpg|BK005774.1|[148910846]

BK005775             
TPA_inf: Gallus gallus chromosome 5 TATA box binding protein-like 2 mRNA, complete cds
gi|148910848|tpg|BK005775.1|[148910848]

BK005776             
TPA_inf: Takifugu rubripes TATA box binding protein-like 2 mRNA, complete cds
gi|148910850|tpg|BK005776.1|[148910850]

BK005777             
TPA_inf: Pan troglodytes TATA box binding protein mRNA, complete cds
gi|148910852|tpg|BK005777.1|[148910852]

BK005778             
TPA_inf: Takifugu rubripes TATA box binding protein mRNA, complete cds
gi|148910854|tpg|BK005778.1|[148910854]

BK005779             
TPA_inf: Pan troglodytes chromosome 6 TATA box binding protein-like 1 mRNA, complete cds
gi|148910856|tpg|BK005779.1|[148910856]

BK005780             
TPA_inf: Takifugu rubripes TATA box binding protein-like 1 mRNA, complete cds
gi|148910858|tpg|BK005780.1|[148910858]

DQ448593            
Homo sapiens TATA box binding protein like 2 mRNA, complete cds
gi|90296775|gb|DQ448593.1|[90296775]

NM_001032673    
Takifugu rubripes TBP-related factor 3 (TRF3), mRNA
gi|74095978|ref|NM_001032673.1|[74095978]

NM_001090499    
Xenopus laevis manganese superoxide dismutase (Sod2), mRNA
gi|147899554|ref|NM_001090499.1|[147899554]

NM_001098853    
Gallus gallus TATA box binding protein like 2 (TBPL2), mRNA
gi|149642958|ref|NM_001098853.1|[149642958]

NM_001099292    
Pan troglodytes TBP-like 1 (TBPL1), mRNA
gi|150010555|ref|NM_001099292.1|[150010555]

NM_001099361    
Rattus norvegicus similar to TBP-related factor 3 (LOC680050), mRNA
gi|150247084|ref|NM_001099361.1|[150247084]

NM_001099794    
Takifugu rubripes TATA box binding protein (tbp), mRNA
gi|153792244|ref|NM_001099794.1|[153792244]

NM_001099795    
Takifugu rubripes TATA box binding protein-like 1 (tbpl1), mRNA
gi|153791986|ref|NM_001099795.1|[153791986]

NM_001104606    
Pan troglodytes TATA box binding protein like 2 (TBPL2), mRNA
gi|157265560|ref|NM_001104606.1|[157265560]

NM_001104607    
Pan troglodytes TATA box binding protein (TBP), mRNA
gi|157265562|ref|NM_001104607.1|[157265562]

NM_199047          
Homo sapiens TATA box binding protein like 2 (TBPL2), mRNA
gi|93277103|ref|NM_199047.2|[93277103]

NM_199059          
Mus musculus TATA box binding protein like 2 (Tbpl2), mRNA
gi|39979629|ref|NM_199059.1|[39979629]

Courses Credits Lessons Slides

Corso di Laura in Medicina e Chirurgia

Biologia e Genetica - Canale C

10

Mar, Mer, Ven (09,00:11,00)

 

Corso di Laura in Scienze Infermieristiche

Biologia e Genetica - Polo A

2